AustralieFrV1, Main, Exploration, bibRecord, 005086

Associations between immune depression and cardiovascular events in HIV infection

Identifieur interne : 005086 ( Main/Exploration ); précédent : 005085; suivant : 005087

Associations between immune depression and cardiovascular events in HIV infection

Auteurs : Caroline A. Sabin [Royaume-Uni] ; Lene Ryom [Danemark] ; Stephane De Wit [Belgique] ; Amanda Mocroft [Royaume-Uni] ; Andrew N. Phillips [Royaume-Uni] ; Signe W. Worm [Danemark] ; Rainer Weber [Suisse] ; Antonella D'Arminio Monforte [Italie] ; Peter Reiss [Pays-Bas] ; David Kamara [Royaume-Uni] ; Wafaa El-Sadr [États-Unis] ; Christian Pradier [France] ; Francois Dabis [France] ; Matthew Law [Australie] ; Jens Lundgren [Danemark]

Source :

AIDS : (London) [ 0269-9370 ] ; 2013.

RBID : Pascal:14-0010583

Descripteurs français

Pascal (Inist)
- Etat dépressif, SIDA, Pathologie de l'appareil circulatoire, Lymphocyte, Infarctus du myocarde, Accident cérébrovasculaire, Antigène CD4.

English descriptors

KwdEn :
- AIDS, Cardiovascular disease, Depression, Lymphocyte, Myocardial infarction, Stroke.

Abstract

Objective: To consider associations between the latest/nadir CD4⁺ cell count, and time spent with CD4⁺cell count less than 200 cells/μl (duration of immune depression), and myocardial infarction (Ml), coronary heart disease (CHD), stroke, or cardiovascular disease (CVD) (CHD or stroke) in 33301 HIV-positive individuals. Design: Longitudinal cohort study. Methods: Analyses were undertaken using Poisson regression. To investigate whether analyses of stroke were robust to the type of endpoint, we additionally included stroke-like events and rejected strokes into the stroke endpoint. Results: Participants experienced 716 Ml, 1056 CHD, 303 stroke, and 1284 CVD events. Whereas there was no evidence of a higher Ml/CHD risk in those with lower latest/nadir CD4⁺ cell counts after adjustment [current CD4⁺ < 100 cells/μl: relative rate (95% confidence interval) 0.96 (0.62-1.50) for Ml, 0.89 (0.30-2.36) for CHD; nadir CD4⁺ < 100cells/μl: 1.36 (0.57-3.23) for Ml, 0.98 (0.45-2.16) for CHD], stroke and CVD rates were higher in those with a latest CD4⁺ cell count less than 100 cells/μl [2.26 (1.29-3.94) and 1.14 (0.84-1.56), respectively]. All events occurred less frequently in those who had not experienced immune depression, although evidence for a linear association with duration of immune depression was weak. The association between stroke risk and the latest CD4⁺ cell count strengthened as stroke-like and rejected strokes were included; conversely, associations with established stroke risk factors weakened. Conclusion: We do not find strong evidence that HIV-positive individuals with a low CD4⁺ cell count are more likely to experience MI/CHD. Although strokes appear to occur more commonly at low CD4⁺ cell counts, this may be partly explained by misclassification or other biases.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Associations between immune depression and cardiovascular events in HIV infection</title>
<author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name>
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<author><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name>
<affiliation wicri:level="2"><inist:fA14 i1="07"><s1>ICAP-Columbia University/Harlem Hospital</s1>
<s2>New York</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Département de Santé Publique, Centre Hospitalier Universitaire</s1>
<s2>Nice</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Nice</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>INSERM, Centre INSERM U897 'Epidémiologie et Biostatistique'</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Université Bordeaux Segalen, Institut de Santé Publique Epidémiologie Développement (ISPED)</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
<settlement type="city">Bordeaux</settlement>
</placeName>
<orgName type="university">Université Bordeaux II</orgName>
</affiliation>
</author>
<author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Kirby Institute, University of New South Wales</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundgren, Jens" sort="Lundgren, Jens" uniqKey="Lundgren J" first="Jens" last="Lundgren">Jens Lundgren</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Copenhagen HIV Programme, University of Copenhagen</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Epidemiklinikken M5132, Copenhagen University Hospital/Rigshospitalet</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">AIDS : (London)</title>
<title level="j" type="abbreviated">AIDS : (Lond.)</title>
<idno type="ISSN">0269-9370</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">AIDS : (London)</title>
<title level="j" type="abbreviated">AIDS : (Lond.)</title>
<idno type="ISSN">0269-9370</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Cardiovascular disease</term>
<term>Depression</term>
<term>Lymphocyte</term>
<term>Myocardial infarction</term>
<term>Stroke</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Etat dépressif</term>
<term>SIDA</term>
<term>Pathologie de l'appareil circulatoire</term>
<term>Lymphocyte</term>
<term>Infarctus du myocarde</term>
<term>Accident cérébrovasculaire</term>
<term>Antigène CD4</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: To consider associations between the latest/nadir CD4<sup>+</sup>
 cell count, and time spent with CD4<sup>+ </sup>
cell count less than 200 cells/μl (duration of immune depression), and myocardial infarction (Ml), coronary heart disease (CHD), stroke, or cardiovascular disease (CVD) (CHD or stroke) in 33301 HIV-positive individuals. Design: Longitudinal cohort study. Methods: Analyses were undertaken using Poisson regression. To investigate whether analyses of stroke were robust to the type of endpoint, we additionally included stroke-like events and rejected strokes into the stroke endpoint. Results: Participants experienced 716 Ml, 1056 CHD, 303 stroke, and 1284 CVD events. Whereas there was no evidence of a higher Ml/CHD risk in those with lower latest/nadir CD4<sup>+</sup>
 cell counts after adjustment [current CD4<sup>+</sup>
 < 100 cells/μl: relative rate (95% confidence interval) 0.96 (0.62-1.50) for Ml, 0.89 (0.30-2.36) for CHD; nadir CD4<sup>+</sup>
 < 100cells/μl: 1.36 (0.57-3.23) for Ml, 0.98 (0.45-2.16) for CHD], stroke and CVD rates were higher in those with a latest CD4<sup>+</sup>
 cell count less than 100 cells/μl [2.26 (1.29-3.94) and 1.14 (0.84-1.56), respectively]. All events occurred less frequently in those who had not experienced immune depression, although evidence for a linear association with duration of immune depression was weak. The association between stroke risk and the latest CD4<sup>+</sup>
 cell count strengthened as stroke-like and rejected strokes were included; conversely, associations with established stroke risk factors weakened. Conclusion: We do not find strong evidence that HIV-positive individuals with a low CD4<sup>+</sup>
 cell count are more likely to experience MI/CHD. Although strokes appear to occur more commonly at low CD4<sup>+</sup>
 cell counts, this may be partly explained by misclassification or other biases.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>Danemark</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Aquitaine</li>
<li>Canton de Zurich</li>
<li>Grand Londres</li>
<li>Hollande-Septentrionale</li>
<li>Hovedstaden</li>
<li>Lombardie</li>
<li>Nouvelle-Aquitaine</li>
<li>Nouvelle-Galles du Sud</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Région de Bruxelles-Capitale</li>
<li>État de New York</li>
</region>
<settlement><li>Amsterdam</li>
<li>Bordeaux</li>
<li>Bruxelles</li>
<li>Copenhague</li>
<li>Londres</li>
<li>Milan</li>
<li>Nice</li>
<li>Sydney</li>
<li>Zurich</li>
</settlement>
<orgName><li>Université Bordeaux II</li>
<li>Université de Zurich</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name>
</region>
<name sortKey="Kamara, David" sort="Kamara, David" uniqKey="Kamara D" first="David" last="Kamara">David Kamara</name>
<name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name>
<name sortKey="Phillips, Andrew N" sort="Phillips, Andrew N" uniqKey="Phillips A" first="Andrew N." last="Phillips">Andrew N. Phillips</name>
</country>
<country name="Danemark"><region name="Hovedstaden"><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name>
</region>
<name sortKey="Lundgren, Jens" sort="Lundgren, Jens" uniqKey="Lundgren J" first="Jens" last="Lundgren">Jens Lundgren</name>
<name sortKey="Lundgren, Jens" sort="Lundgren, Jens" uniqKey="Lundgren J" first="Jens" last="Lundgren">Jens Lundgren</name>
<name sortKey="Worm, Signe W" sort="Worm, Signe W" uniqKey="Worm S" first="Signe W." last="Worm">Signe W. Worm</name>
</country>
<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name>
</region>
</country>
<country name="Suisse"><region name="Canton de Zurich"><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name>
</region>
</country>
<country name="Italie"><region name="Lombardie"><name sortKey="Monforte, Antonella D Arminio" sort="Monforte, Antonella D Arminio" uniqKey="Monforte A" first="Antonella D'Arminio" last="Monforte">Antonella D'Arminio Monforte</name>
</region>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name>
</region>
</country>
<country name="États-Unis"><region name="État de New York"><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name>
</region>
</country>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name>
</region>
<name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name>
<name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Associations between immune depression and cardiovascular events in HIV infection

Associations between immune depression and cardiovascular events in HIV infection

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